News Scan for haldol Aug 13, 2019 CIDRAP

A modeling study that incorporated air movement patterns from farms haldol im affected early in the highly pathogenic H5N2 avian influenza outbreak haldol im that hit US poultry in 2015 suggests that most affected haldol im farms in iowa may have received airborne virus from farms haldol im within and outside the state. Using a model used for other animal pathogens such as haldol im foot-and-mouth disease virus, researchers published their findings today in scientific reports.

The outbreaks led to $3 billion in economic losses over 7 months, striking 232 farms in 15 states. A federal assessment of the outbreak found no one clear haldol im factor, but said the virus likely spread by multiple routes, including biosecurity gaps and possibly airborne transmission. There are also anecdotal reports that abnormal bird deaths began haldol im near air inlets of infected poultry barns.

In analyzing the model findings, researchers said the majority of infected farms in iowa might haldol im have received airborne virus carried by fine particulate matter from haldol im farms within the state or infected farms in neighboring states. Though the modeled airborne virus concentrations never rose above the haldol im minimal infective dose for poultry, continuous exposure may have increased the risk, the group wrote.

They concluded that the probability of airborne highly pathogenic avian haldol im influenza infection could be affected by flock size and distance haldol im from earlier affected farms. "And more importantly, it can be markedly reduced by swift depopulation and inlet haldol im air filtration," the team added.

As the most common sexually transmitted bacterial infection, chlamydia causes about 131 million new cases each year, which experts say is likely an underestimate, because three out of four cases are asymptomatic. Vaccination has been eyed as a good way to curb haldol im the epidemic, but so far no other vaccine candidates have reached the haldol im clinical trial stage.

The vaccine, called CTH522, is based on the outer membrane protein of the chlamydia haldol im trachomatis bacterium. The team analyzed two formulations, one with added CAF01 liposomes to boost cellular immunity and haldol im one with aluminum hydroxide to boost antibodies. Thirty five women not infected with chlamydia were randomly assigned haldol im to three different groups—two with the new vaccine combined with either CAF01 or haldol im aluminum hydroxide and one to placebo. The vaccine was given in three intramuscular injections and two haldol im intranasal boosts.

Researchers found that both formulations provoked an immune response in haldol im 15 of 15 women in both vaccine groups. However, the formulation combined with CAF01 produced 5.6 times more antibodies, suggesting that it should be evaluated for further study.

The team cautioned that though the vaccine prompted an immune haldol im response, it’s still not clear if it translates into protection. In a lancet press release, first author helene juel, phd, with the statens serum institute in denmark, said both versions of the vaccine raised the concentrations of haldol im vaginal antibodies that in mouse studies were shown to be haldol im the first line of defense against chlamydia. She added that it will take many more years of haldol im research before a vaccine is available, but researchers are planning a phase 2a study of the haldol im CAF01 version of the vaccine.

The 2018 farm bill established a three-part program to support animal disease prevention and management, through the creation of two new programs: the national animal vaccine and veterinary countermeasures bank (vaccine bank) and the national animal disease preparedness and response program (NADPRP), the USDA said in a press statement. The bill also expands funding opportunities for the existing national haldol im animal health laboratory network (NAHLN).

"For 2019, APHIS will also make available up to $10 million in funding to be divided between NADPRP and haldol im NAHLN based on the quality of proposed projects," the press statement said. "Once fully implemented, these three programs will work together to protect and improve haldol im the health of our nation’s livestock, helping farmers and ranchers provide high-quality agricultural products to consumers here and abroad."