As Threat of Antibiotic Resistance Mounts, Biotechs haldol side effects in elderly Are Running Out of Cash and Time

While the pharmaceutical industry’s powerhouses continue wrestling with lawmakers to gut drug pricing haldol side effects in elderly measures from the agenda, biotechnology companies deep in the antibiotic space are desperate for haldol side effects in elderly capitol hill to take decisive action on an issue somewhat haldol side effects in elderly less likely to command center stage: “superbugs.” the handful of drugmakers focused on developing new antibiotics to haldol side effects in elderly combat these drug-resistant bacteria are running dangerously low on cash, and run the risk of declaring bankruptcy.

The public health community has long fought to raise awareness haldol side effects in elderly of the imminent threat posed by superbugs. Every year, about 2 million U.S. Residents become infected with drug-resistant bacteria; tuberculosis, malaria, HIV and other drug-resistant infections kill nearly 700,000 people worldwide. It’s been just over 30 years since scientists last discovered haldol side effects in elderly a new class of antibiotics. If another three decades pass without meaningful progress, experts warn, the annual death toll from drug-resistant infections is estimated to hit 10 million.

Without new treatment for infections that can arise from procedures haldol side effects in elderly ranging from caesarean sections to hip replacement surgery, what are now common medical operations could rapidly become life-threatening. But despite the looming risk, which has pushed a wave of young biotechnology companies to haldol side effects in elderly seek aggressive congressional and regulatory action, investors still aren’t biting.

“I’ve been speaking with a lot of potential investors on haldol side effects in elderly the private side and on the public side,” said zach zimmerman, chief executive officer at san diego-based forge therapeutics inc. “the message I’m hearing about antibiotics is loud and clear: there’s going to be no more investment in the antibiotic haldol side effects in elderly sector until there is substantial change in the marketplace.”

In many ways, the escalation of antimicrobial resistance is the product of a haldol side effects in elderly collision between two omnipresent threats facing the pharmaceutical industry: the scientific challenge of developing new treatments and market failures haldol side effects in elderly that thwart their pathway to commercial success.

Zimmerman is at the helm of one of the biotech haldol side effects in elderly companies developing “truly novel” antibiotics, rather than new iterations of existing classes. But forge — along with companies such as entasis therapeutics inc. Of waltham, mass., melinta therapeutics inc. Of new haven, conn., and tetraphase pharmaceuticals inc. Of watertown, mass. — is not exploring uncharted territory. And top executives are acutely aware of how this story haldol side effects in elderly ends in the absence of a market fix.

Achaogen inc., a drugmaker based in south san francisco, calif., that spent years developing an antibiotic for a drug-resistant infection commonly found in intensive care settings, filed for chapter 11 bankruptcy in april, less than a year after its treatment zemdri won federal haldol side effects in elderly approval. Several other companies with late-stage antibiotics have already undergone rounds of layoffs, gutted research programs or begun selling laboratory equipment.

Greg frank, the director of infectious disease policy at the biotechnology innovation haldol side effects in elderly organization, said achaogen’s fate sent a grave signal to companies in this haldol side effects in elderly space that are clamoring to prove their products’ success before cash runs out.

“achaogen was the first to go bankrupt. If three or four more companies also go bankrupt, the ripple effects this will have on what’s left of the antimicrobial pipeline will be quite dire,” frank said. “we need to have swift action and signs from the haldol side effects in elderly U.S. Government, congress and the administration that they are really acting on haldol side effects in elderly this issue and trying to address it comprehensively.”

Frank is spearheading “ working to fight AMR ,” the first public-facing coalition sounding the alarm on this issue in washington. The group’s first order of business is advocating for legislation to haldol side effects in elderly catalyze development of new medication, most notably sens. Johnny isakson (R-ga.) and bob casey’s (D-pa.) DISARM act , which would adjust how medicare reimburses hospitals for certain antibiotics haldol side effects in elderly and offer additional funding to hospitals when qualifying drugs are haldol side effects in elderly appropriately deployed.

Eric kimble, chief commercial officer at entasis, said that by nature, antibiotics — short-term drugs intended to be a lifesaving last resort — face a unique set of “perverse” incentives riddling the health system that threatens investment in this haldol side effects in elderly arena. For one, hospitals are reimbursed at lower rates for using novel, pricier medications, even if lower-cost generics are drug-resistant. The disincentive for buying new products means antibiotics don’t drive profit, and financial backers don’t see a solid return on their investment.

The DISARM act is no silver bullet, but industry leaders say the investor community has indicated its haldol side effects in elderly passage would send a message in favor of giving these haldol side effects in elderly antibiotic-focused companies a lifeline. Until then, biotech companies are trying to make their limited financial resources haldol side effects in elderly last.

Boston-based paratek pharmaceuticals inc. Has a drug for urinary tract infections in phase two haldol side effects in elderly of a clinical trial now, but adam woodrow, the company’s president and chief commercial officer, says it will be very difficult to raise the financial haldol side effects in elderly capital for phase three — despite the fact that paratek is in a relatively healthy haldol side effects in elderly position compared to others in its peer group and is haldol side effects in elderly currently selling that drug to treat community acquired bacterial pneumonia haldol side effects in elderly and acute skin infections. Ruben tommasi, chief scientific officer at entasis, said the drugmaker has just enough on hand to “crack the envelope” for one of its products to determine whether it’s been successful, but no more after that.

From a public health perspective, there are frightening parallels between the rise of superbugs and haldol side effects in elderly the opioid epidemic, zimmerman noted. The government was warned by federal scientists of the mounting haldol side effects in elderly risk of opioid addiction and abuse; in the same vein, infectious disease experts have been monitoring drug-resistant bacteria across the globe and the united states for haldol side effects in elderly decades and “know it’s only going to get worse.”

What’s more, drug resistance is already here. The centers for disease control and prevention has changed its haldol side effects in elderly guidelines for gonorrhea treatment six times in the past 20 haldol side effects in elderly years because of the infection’s aptitude for developing resistance. The risk of bankruptcy for companies desperately seeking funding to haldol side effects in elderly develop antibiotics is a matter of a couple years, if that.

According to zimmerman, forge has heard some positive news from federal agencies about haldol side effects in elderly a market stabilization initiative — perhaps a fixed-purchase or stockpile process that would guarantee companies some flow haldol side effects in elderly of revenue. That’s critical, he said, because companies need ammunition to show investors that even if haldol side effects in elderly a product isn’t a blockbuster, it can deliver solid returns on investment.

Experts acknowledged that recent action by the centers for medicare haldol side effects in elderly and medicaid services on addressing reimbursement challenges has been promising, but they aren’t stopping to celebrate any victories just yet. In the meantime, some companies are eyeing opportunities for consolidation.

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